787 research outputs found

    Cortical fMRI activation to opponents' body kinematics in sport-related anticipation: Expert-novice differences with normal and point-light video

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    This is the post-print version of the final paper published in Neuroscience Letters. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. Copyright @ 2011 Elsevier B.V.Badminton players of varying skill levels viewed normal and point-light video clips of opponents striking the shuttle towards the viewer; their task was to predict in which quadrant of the court the shuttle would land. In a whole-brain fMRI analysis we identified bilateral cortical networks sensitive to the anticipation task relative to control stimuli. This network is more extensive and localised than previously reported. Voxel clusters responding more strongly in experts than novices were associated with all task-sensitive areas, whereas voxels responding more strongly in novices were found outside these areas. Task-sensitive areas for normal and point-light video were very similar, whereas early visual areas responded differentially, indicating the primacy of kinematic information for sport-related anticipation.Research Grants Council of the Hong Kong Special Administrative Region, Chin

    Segregation analysis comparing liability and quantitative trait models for hypertension using the Genetic Analysis Workshop 13 simulated data

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    Discrete (qualitative) data segregation analysis may be performed assuming the liability model, which involves an underlying normally distributed quantitative phenotype. The appropriateness of the liability model for complex traits is unclear. The Genetic Analysis Workshop 13 simulated data provides measures on systolic blood pressure, a highly complex trait, which may be dichotomized into a discrete trait (hypertension). We perform segregation analysis under the liability model of hypertensive status as a qualitative trait and compare this with results using systolic blood pressure as a quantitative trait (without prior knowledge at that stage of the true underlying simulation model) using 1050 pedigrees ascertained from four replicates on the basis of at least one affected member. Both analyses identify models with major genes and polygenic components to explain the family aggregation of systolic blood pressure. Neither of the methods estimates the true parameters well (as the true model is considerably more complicated than those considered for the analysis), but both identified the most complicated model evaluated as the preferred model. Segregation analysis of complex diseases using relatively simple models is unlikely to provide accurate parameter estimates but is able to indicate major gene and/or polygenic components in familial aggregation of complex diseases

    Functional imaging of cortical responses in expert and novice badminton players while predicting the direction of a badminton stroke

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    This journal suppl. entitled: Special Issue: 15th Annual Meeting of the Organization for Human Brain MappingINTRODUCTION: Abernethy et al. (2008) showed that expert badminton players can use the kinematic information of the opponent's body movement to predict the direction of a stroke. The purpose of the present study was to compare the brain activity of expert and novice badminton players while carrying out a similar anticipation task. METHODS: In a block design fMRI study, participants viewed 2 s video displays of an opposing player, and pressed a button to indicate which of four possible court positions a stroke was directed. Individual trials were occluded either 80 ms before or 80ms after the ...postprin
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